Peter Ten Dijke Selected Research

Transforming Growth Factors (Transforming Growth Factor)

10/2022	RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis.
9/2022	Synthesis and preclinical evaluation of [11C]LR111 and [18F]EW-7197 as PET tracers of the activin-receptor like kinase-5.
1/2022	OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor.
1/2022	Establishment of Embryonic Zebrafish Xenograft Assays to Investigate TGF-β Family Signaling in Human Breast Cancer Progression.
1/2022	Transforming growth factor-β challenge alters the N-, O-, and glycosphingolipid glycomes in PaTu-S pancreatic adenocarcinoma cells.
1/2022	Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling.
1/2022	Low Transforming Growth Factor-β Pathway Activity in Cervical Adenocarcinomas.
11/2021	Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis.
1/2021	Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression.
1/2020	On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?

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Peter Ten Dijke Research Topics

Disease

56	Neoplasms (Cancer) 10/2022 - 04/2002
21	Breast Neoplasms (Breast Cancer) 10/2022 - 09/2007
18	Neoplasm Metastasis (Metastasis) 01/2022 - 09/2007
9	Fibrosis (Cirrhosis) 01/2022 - 09/2009
8	Inflammation (Inflammations) 01/2022 - 08/2002
6	Pulmonary Arterial Hypertension 01/2022 - 08/2013
5	Myositis Ossificans (Fibrodysplasia Ossificans Progressiva) 02/2021 - 01/2010
5	Carcinogenesis 01/2021 - 09/2011
4	Hereditary Hemorrhagic Telangiectasia 07/2022 - 09/2009
4	Colorectal Neoplasms (Colorectal Cancer) 05/2022 - 05/2008
3	Pulmonary Hypertension 01/2022 - 08/2013
3	Adenocarcinoma 01/2022 - 01/2020
2	Urinary Bladder Neoplasms (Bladder Cancer) 10/2022 - 01/2019
2	Vascular Malformations 07/2022 - 01/2021
2	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 10/2021
2	Hypertrophy 11/2021 - 08/2013
2	Osteoarthritis 11/2021 - 01/2017
2	Hypoxia (Hypoxemia) 06/2020 - 08/2013
2	Vascular Remodeling 06/2020 - 05/2003
2	Heterotopic Ossification (Ectopic Ossification) 11/2019 - 01/2012
2	Colonic Neoplasms (Colon Cancer) 01/2019 - 11/2012
2	Diabetic Nephropathies (Diabetic Nephropathy) 11/2017 - 01/2017
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017 - 07/2003
2	Prostatic Neoplasms (Prostate Cancer) 01/2017 - 09/2007
2	Infections 11/2016 - 08/2015
2	Dupuytren Contracture (Dupuytrens Contracture) 01/2014 - 06/2011
2	Vascular Diseases (Vascular Disease) 01/2014 - 09/2009
2	Telangiectasis (Telangiectasia) 09/2009 - 02/2005
1	Hepatitis B 05/2022
1	Acute Liver Failure (Fulminant Hepatic Failure) 01/2022
1	Acute-On-Chronic Liver Failure 01/2022

Drug/Important Bio-Agent (IBA)

25	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2022 - 01/2011
17	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 10/2022 - 08/2002
16	Proteins (Proteins, Gene)FDA Link 10/2022 - 08/2002
11	Phosphotransferases (Kinase)IBA 01/2022 - 09/2011
9	CytokinesIBA 01/2022 - 01/2016
9	Transforming Growth Factor beta (TGF-beta)IBA 01/2022 - 04/2002
7	Pharmaceutical PreparationsIBA 01/2022 - 11/2012
6	Biomarkers (Surrogate Marker)IBA 10/2022 - 01/2017
6	Activin Receptors (Activin Receptor)IBA 11/2021 - 08/2002
5	CarcinogensIBA 10/2022 - 04/2002
5	Messenger RNA (mRNA)IBA 01/2022 - 08/2002
5	Bone Morphogenetic Protein ReceptorsIBA 01/2022 - 05/2008
5	Activins (Activin)IBA 01/2017 - 11/2016
4	Deubiquitinating EnzymesIBA 01/2022 - 01/2016
4	Type I Bone Morphogenetic Protein ReceptorsIBA 06/2021 - 01/2010
4	EndoglinIBA 01/2020 - 02/2005
4	Transcription Factors (Transcription Factor)IBA 11/2019 - 01/2016
4	LigandsIBA 11/2019 - 08/2002
3	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2022 - 06/2020
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2020 - 11/2012
3	ErbB Receptors (EGF Receptor)IBA 01/2020 - 11/2012
3	CollagenIBA 11/2019 - 01/2017
3	Growth Differentiation Factor 2IBA 01/2018 - 01/2017
2	TNF Receptor-Associated Factor 4IBA 10/2022 - 09/2013
2	Phenobarbital (Luminal)FDA Link 10/2022 - 09/2007
2	activin AIBA 07/2022 - 11/2019
2	1-phenyl-3,3-dimethyltriazene (PDT)IBA 05/2022 - 01/2022
2	Photosensitizing Agents (Photosensitizers)IBA 05/2022 - 01/2022
2	Oxygen (Dioxygen)IBA 05/2022 - 11/2011
2	NestinIBA 01/2022 - 10/2021
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 10/2011
2	Cadherins (E-Cadherin)IBA 01/2022 - 09/2007
2	Immune Checkpoint InhibitorsIBA 12/2021 - 01/2020
2	GlycosphingolipidsIBA 01/2021 - 01/2020
2	Polysaccharides (Glycans)IBA 01/2021 - 01/2020
2	Tacrolimus (Prograf)FDA LinkGeneric 11/2020 - 08/2013
2	Epidermal Growth Factor (EGF)IBA 01/2020 - 11/2019
2	Cytostatic AgentsIBA 11/2019 - 01/2016
2	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2018 - 01/2016
2	Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)IBA 01/2017 - 01/2017
2	CateninsIBA 01/2016 - 05/2011
2	IntegrinsIBA 02/2015 - 02/2012
2	Bone Morphogenetic Protein 7IBA 02/2012 - 09/2007
2	Glycogen Synthase KinasesIBA 09/2011 - 05/2011
2	VimentinIBA 09/2007 - 09/2007
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2022
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 10/2022
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 10/2022
1	VaccinesIBA 05/2022
1	temoporfinIBA 05/2022
1	Immunologic Factors (Immunomodulators)IBA 01/2022
1	Ubiquitin-Specific ProteasesIBA 01/2022
1	HydrogelsIBA 01/2022
1	Peptidylprolyl Isomerase (Prolyl Isomerase)IBA 01/2022
1	Indicators and Reagents (Reagents)IBA 01/2022
1	Platelet-Derived Growth FactorIBA 01/2022
1	6-formylindolo(3,2-b)carbazoleIBA 01/2022
1	Protein Kinases (Protein Kinase)IBA 01/2022
1	enhanced green fluorescent proteinIBA 01/2022
1	FollistatinIBA 01/2022
1	LectinsIBA 01/2022

Therapy/Procedure

20	Therapeutics 05/2022 - 08/2011
5	Drug Therapy (Chemotherapy) 01/2022 - 11/2012
4	Immunotherapy 01/2022 - 01/2019
3	Radiotherapy 01/2022 - 02/2009
3	Transplantation 12/2017 - 01/2017
2	Photochemotherapy (Photodynamic Therapy) 05/2022 - 01/2022
2	Lasers (Laser) 05/2022 - 09/2007
2	Ligation 01/2016 - 07/2003